What is lisinopril/hydrochlorothiazide used for? Lisinopril/hydrochlorothiazide is commonly used to lower high blood pressure (hypertension). Lowering high blood pressure has been shown to. Lisinopril/hydrochlorothiazide (Zestoretic) is an oral medication used to treat high blood pressure. Learn about side effects, warnings, dosage, and more. Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Know what Lisinopril-HCTZ is used for, how to take it, and which side effects to expect when starting it. Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] Description Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings. Learn about Zestoretic (lisinopril / hydrochlorothiazide) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Learn about the side effects of hydrochlorothiazide/lisinopril, from common to rare, for consumers and healthcare professionals.