lisinopril and hydrochlorothiazide ( Zestoretic, Prinzide) is a combination of drugs prescribed to treat hypertension (high blood pressure), side effects and drug interactions should be discussed with your doctor before taking this medication. Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Detailed Hydrochlorothiazide / Lisinopril dosage information for adults. Includes dosages for Hypertension; plus renal, liver and dialysis adjustments. The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. Learn about Zestoretic (lisinopril / hydrochlorothiazide) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Find patient medical information for Lisinopril/Hydrochlorothiazide (Prinzide, Zestoretic) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings. Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2].